Cleft lip and palate are present in one of 1000 live Caucasian births. The incidence of cleft palate alone is one in 500 live births. Considering the cleft deformities of all races grouped together, 50% are cleft lip and palate, 30-35% are palate only, and 15-20% are cleft lip only.
The genetics of cleft lip and palate are not classical Mendelian, but siblings of cleft patients are at greater risk. The risk is directly related to the frequency and severity of the clefts. Approximately 10% of patients with a cleft deformity will have other anomalies at birth.
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